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6 The practical takeaway for you: correcting a genuine selenium shortfall is worth doing, but piling extra selenium on top of an adequate intake isn't supported, and, as the next sections explain, it carries real risk

The broader picture is one in which MOTS-c addresses a gap that many other longevity interventions leave unfilled: the mitochondrial signaling decline that is simultaneously a cause and consequence of metabolic aging

(2020) 14:e0008495

Patients with autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and T1D, have been shown to have lower levels of CTLA4 mRNA (85)